Mesenchymal Stem cells - hES-MSC / T-MSC

 

 

Mesenchymal Stem Cells:

Mesenchymal stem cells (MSCs) are multipotent, and can differentiate into multiple cell types, including adipocytes, cartilage, bone, tendons, muscle, and skin. MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues. MSCs have also been used to treat heart failure and acute heart infarction due to their ability to differentiate into cardiomyocytes and vascular endothelial cells and to secrete angiogenic and anti-apoptotic factors. MSCs also have strong immune suppressive function, which is being used to treat many autoimmune diseases.

 

 

hES-MSC:
hESC now can be differentiated into MSC with high efficiency and purity without cell supply concerns. hESC have great advantages over traditional adult-tissue derived MSCs, such as bone marrow MSC (BM-MSC), placenta MSC (hPMSC). See our Stem Cell Report publication for detail.

See the chart below for comparison between hES-MSC and BM-MSC

 

 

 

hESC-MSC

BM-MSC(adult-tissue derived)

Origin of cell

Human Embryonic Stem cell

Bone marrow or Placenta

Supply

Unlimited, stable

Limited supply

Quality variance

NO

Donor variance
Batch variance
Passage Variance
Manufacture variance

Immunosuppressive activity

Strong both in vitro/in vivo

poor, or not working

Consistency

Yes
Resistant to environment change

No
Changes after expansion and infusion into different patient

Senescent/Aging

No

Easy

Foreign pathogen

NO

Possible, need test every donor

Immunogenicity

Low

medium

Inflammatory cytokine release

No

Medium to high

Manufacture Time/cost

Short, low

Long, variable

 

T-MSC:


 

There are many ways to derive MSC from hES cells. Our proprietary method of derive MSC from hES cells are the most efficient method, with shortest time, highest yield and purity. This method outperforms other current methods by at least 200 times in cell yield, 50~80% less the processing time, 75% less the manufacturing cost. We have confirmed that our T-MSC have strong therapeutic effects in multiple sclerosis animal model. In our recent study, we have also confirmed that our cells outperform all adult-tissue derived mesenchymal stem cells in treating multiple autoimmune diseases.

 

T-MSC Platform:

T-MSC is not only a product or technology, but also a platform can be widely used in many areas as show below: